Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2
نویسندگان
چکیده
منابع مشابه
Notch inhibition during corneal epithelial wound healing promotes migration.
PURPOSE To determine the role of Notch signaling in corneal epithelial migration and wound healing. METHODS Immunolocalization of Notch1 was performed during epithelial wound healing in vivo in mouse corneal epithelial debridement wounds and in vitro in primary human corneal epithelial cells following a linear scratch wound. The effects of Notch inhibition, using the γ-secretase inhibitor N-(...
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Notch signaling is an evolutionarily conserved pathway that plays a central role in numerous developmental and disease processes. The versatility of the Notch pathway relies on the activity of context-dependent regulators. These include rab11, sec15, arp3 and Drosophila EHBP1 (dEHBP1), which control Notch signaling and cell fate acquisition in asymmetrically dividing mechanosensory lineages by ...
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Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2020
ISSN: 0960-9822
DOI: 10.1016/j.cub.2020.01.027